Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression
I Julkunen, T Sareneva, J Pirhonen, T Ronni… - Cytokine & growth factor …, 2001 - Elsevier
Despite vaccines and antiviral substances influenza still causes significant morbidity and
mortality world wide. Better understanding of the molecular mechanisms of influenza virus
replication, pathogenesis and host immune responses is required for the development of
more efficient means of prevention and treatment of influenza. Influenza A virus, which
replicates in epithelial cells and leukocytes, regulates host cell transcriptional and
translational systems and activates, as well as downregulates apoptotic pathways. Influenza …
mortality world wide. Better understanding of the molecular mechanisms of influenza virus
replication, pathogenesis and host immune responses is required for the development of
more efficient means of prevention and treatment of influenza. Influenza A virus, which
replicates in epithelial cells and leukocytes, regulates host cell transcriptional and
translational systems and activates, as well as downregulates apoptotic pathways. Influenza …