Uptake of polymyxin B into renal cells
K Abdelraouf, KT Chang, T Yin, M Hu… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Antimicrobial agents and chemotherapy, 2014•Am Soc Microbiol
Polymyxin B is increasingly used as a treatment of last resort against multidrug-resistant
Gram-negative infections. Using a mammalian kidney cell line, we demonstrated that
polymyxin B uptake into proximal tubular epithelial cells was saturable and occurred
primarily through the apical membrane, suggesting the involvement of transporters in the
renal uptake of polymyxin B. Megalin might play a role in the uptake and accumulation of
polymyxin B into renal cells.
Gram-negative infections. Using a mammalian kidney cell line, we demonstrated that
polymyxin B uptake into proximal tubular epithelial cells was saturable and occurred
primarily through the apical membrane, suggesting the involvement of transporters in the
renal uptake of polymyxin B. Megalin might play a role in the uptake and accumulation of
polymyxin B into renal cells.
Abstract
Polymyxin B is increasingly used as a treatment of last resort against multidrug-resistant Gram-negative infections. Using a mammalian kidney cell line, we demonstrated that polymyxin B uptake into proximal tubular epithelial cells was saturable and occurred primarily through the apical membrane, suggesting the involvement of transporters in the renal uptake of polymyxin B. Megalin might play a role in the uptake and accumulation of polymyxin B into renal cells.
American Society for Microbiology