The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells.
M Vaara, T Vaara - 2013 - cabidigitallibrary.org
M Vaara, T Vaara
2013•cabidigitallibrary.orgThis article compares the cytotoxicity of NAB739 with that of polymyxin B. It can be
concluded that the toxicity of NAB739 to HK-2 cells is only approximately one-twenty-fifth
that of polymyxin B, whilst its antibacterial activity against Escherichia coli is identical to that
of polymyxin B and the activity against Klebsiella pneumoniae is one-half that of polymyxin
B.
concluded that the toxicity of NAB739 to HK-2 cells is only approximately one-twenty-fifth
that of polymyxin B, whilst its antibacterial activity against Escherichia coli is identical to that
of polymyxin B and the activity against Klebsiella pneumoniae is one-half that of polymyxin
B.
Abstract
This article compares the cytotoxicity of NAB739 with that of polymyxin B. It can be concluded that the toxicity of NAB739 to HK-2 cells is only approximately one-twenty-fifth that of polymyxin B, whilst its antibacterial activity against Escherichia coli is identical to that of polymyxin B and the activity against Klebsiella pneumoniae is one-half that of polymyxin B.
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