Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response
ML Becker, LE Visser, RHN van Schaik… - Pharmacogenetics …, 2010 - journals.lww.com
Objective Metformin is transported into the hepatocyte by organic cation transporter 1
(OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we
discovered that polymorphisms rs622342 A> C in the SLC22A1 gene, coding for OCT1, and
rs2289669 G> A in the SLC47A1 gene, coding for MATE1, are associated with the degree of
glucose lowering by metformin. In this study, we assessed whether there exists an
interaction between these two polymorphisms. Methods We identified all incident metformin …
(OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we
discovered that polymorphisms rs622342 A> C in the SLC22A1 gene, coding for OCT1, and
rs2289669 G> A in the SLC47A1 gene, coding for MATE1, are associated with the degree of
glucose lowering by metformin. In this study, we assessed whether there exists an
interaction between these two polymorphisms. Methods We identified all incident metformin …