Crescentic glomerulonephritis (GN) in a renal biopsy is a widely accepted “critical diagnosis”
in Anatomic Pathology practice. Prompt biopsy evaluation and notification of the referring
physician is essential to facilitate rapid therapeutic intervention. The differential diagnostic
categories of crescentic GN include pauci-immune GN, anti-glomerular basement
membrane (GBM) nephritis and immune complex-mediated GN, distinguished from one
another by immunofluorescence and electron microscopic study of the renal biopsy. Immune …