Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy

ACT Palei, VC Sandrim, LM Amaral… - … and molecular pathology, 2012 - Elsevier
We examined whether two functional polymorphisms (g.-1306C> T and g.-735C> T) in
matrix metalloproteinase (MMP)-2 gene are associated with preeclampsia (PE) or
gestational hypertension (GH), and whether they modify MMP-2 or tissue inhibitor of
metalloproteinase (TIMP)-2 plasma concentrations in these hypertensive disorders of
pregnancy. We studied 130 healthy pregnant (HP), 130 pregnant with GH, and 133 pregnant
with PE. Genomic DNA was extracted from whole blood and genotypes for g.-1306C> T and …