Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
Objective To determine the effects of low-dose prolonged methylprednisolone infusion on
lung function in patients with early severe ARDS. Design Randomized, double-blind,
placebo-controlled trial. Setting ICUs of five hospitals in Memphis. Participants Ninety-one
patients with severe early ARDS (≤ 72 h), 66% with sepsis. Interventions Patients were
randomized (2: 1 fashion) to methylprednisolone infusion (1 mg/kg/d) vs placebo. The
duration of treatment was up to 28 days. Infection surveillance and avoidance of paralysis …
lung function in patients with early severe ARDS. Design Randomized, double-blind,
placebo-controlled trial. Setting ICUs of five hospitals in Memphis. Participants Ninety-one
patients with severe early ARDS (≤ 72 h), 66% with sepsis. Interventions Patients were
randomized (2: 1 fashion) to methylprednisolone infusion (1 mg/kg/d) vs placebo. The
duration of treatment was up to 28 days. Infection surveillance and avoidance of paralysis …