[HTML][HTML] MUC1-C oncoprotein activates ERK→ C/EBPβ signaling and induction of aldehyde dehydrogenase 1A1 in breast cancer cells
M Alam, R Ahmad, H Rajabi, A Kharbanda… - Journal of Biological …, 2013 - ASBMB
Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is used as a marker of breast cancer stem
cells; however, little is known about the regulation of ALDH1A1 expression. Mucin 1 (MUC1)
is a heterodimeric protein that is aberrantly overexpressed in most human breast cancers. In
studies of breast cancer cells stably silenced for MUC1 or overexpressing the oncogenic
MUC1-C subunit, we demonstrate that MUC1-C is sufficient for induction of MEK→ ERK
signaling and that treatment with a MUC1-C inhibitor suppresses ERK activation. In turn …
cells; however, little is known about the regulation of ALDH1A1 expression. Mucin 1 (MUC1)
is a heterodimeric protein that is aberrantly overexpressed in most human breast cancers. In
studies of breast cancer cells stably silenced for MUC1 or overexpressing the oncogenic
MUC1-C subunit, we demonstrate that MUC1-C is sufficient for induction of MEK→ ERK
signaling and that treatment with a MUC1-C inhibitor suppresses ERK activation. In turn …