IFN-γ-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4+ T cells requires tumor responsiveness to IFN-γ

GL Beatty, Y Paterson - The Journal of Immunology, 2001 - journals.aai.org
GL Beatty, Y Paterson
The Journal of Immunology, 2001journals.aai.org
The importance of CD4+ T cells in the induction of an optimal antitumor immune response
has largely been attributed to their ability to provide costimulatory signals for the priming of
MHC class I-restricted CD8+ CTL. However, many reports have demonstrated a requirement
for CD4+ T cells in the effector phase of tumor rejection indicating a greater responsibility for
CD4+ T cells in controlling tumor outgrowth. We demonstrate here a critical role for CD4+ T
cells in restraining initial tumor development through the inhibition of tumor angiogenesis …
Abstract
The importance of CD4+ T cells in the induction of an optimal antitumor immune response has largely been attributed to their ability to provide costimulatory signals for the priming of MHC class I-restricted CD8+ CTL. However, many reports have demonstrated a requirement for CD4+ T cells in the effector phase of tumor rejection indicating a greater responsibility for CD4+ T cells in controlling tumor outgrowth. We demonstrate here a critical role for CD4+ T cells in restraining initial tumor development through the inhibition of tumor angiogenesis. Using a tumor variant that is unresponsive to IFN-γ, we show that tumor responsiveness to IFN-γ is necessary for IFN-γ-dependent inhibition of tumor angiogenesis by CD4+ T cells. These studies reveal a pivotal role for CD4+ T cells in controlling early tumor development through inhibition of tumor angiogenesis.
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