Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism
MC Hu, K Shiizaki, M Kuro-o… - Annual review of …, 2013 - annualreviews.org
The metabolically active and perpetually remodeling calcium phosphate–based
endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and
phosphate homeostasis that involves multiple organs in terms of mineral flux and endocrine
cross talk. The fibroblast growth factor (FGF)-Klotho endocrine networks epitomize the
complexity of systems biology, and specifically, the FGF23-αKlotho axis highlights the
concept of the skeleton holding the master switch of homeostasis rather than a passive …
endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and
phosphate homeostasis that involves multiple organs in terms of mineral flux and endocrine
cross talk. The fibroblast growth factor (FGF)-Klotho endocrine networks epitomize the
complexity of systems biology, and specifically, the FGF23-αKlotho axis highlights the
concept of the skeleton holding the master switch of homeostasis rather than a passive …
