Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease
Iron deficiency stimulates FGF23 production, but normal osteocytes couple increased FGF23
production with increased cleavage to maintain normal circulating levels of biologically
active hormone. These findings uncover a second level of FGF23 regulation within
osteocytes, failure of which culminates in elevated levels of biologically active FGF23 in
ADHR and perhaps CKD.
production with increased cleavage to maintain normal circulating levels of biologically
active hormone. These findings uncover a second level of FGF23 regulation within
osteocytes, failure of which culminates in elevated levels of biologically active FGF23 in
ADHR and perhaps CKD.
Summary
Iron deficiency stimulates FGF23 production, but normal osteocytes couple increased FGF23 production with increased cleavage to maintain normal circulating levels of biologically active hormone. These findings uncover a second level of FGF23 regulation within osteocytes, failure of which culminates in elevated levels of biologically active FGF23 in ADHR and perhaps CKD.
Lippincott Williams & Wilkins