Ecto-ADP-ribose transferases: cell-surface response to local tissue injury

A Zolkiewska - Physiology, 2005 - journals.physiology.org
A Zolkiewska
Physiology, 2005journals.physiology.org
Ecto-ADP-ribose transferases (ecto-ARTs) catalyze the transfer of ADP-ribose from NAD+ to
arginine residues in cell-surface proteins. Since the concentration of extracellular NAD+ is
very low under normal physiological conditions but rises significantly upon tissue injury or
membrane stress, it is postulated that the main role of ecto-ARTs is to ADP-ribosylate and
regulate the function of certain membrane receptors in response to elevated levels of NAD+.
Ecto-ADP-ribose transferases (ecto-ARTs) catalyze the transfer of ADP-ribose from NAD+ to arginine residues in cell-surface proteins. Since the concentration of extracellular NAD+ is very low under normal physiological conditions but rises significantly upon tissue injury or membrane stress, it is postulated that the main role of ecto-ARTs is to ADP-ribosylate and regulate the function of certain membrane receptors in response to elevated levels of NAD+.
American Physiological Society