Intraoperative high-dose dexamethasone and severe AKI after cardiac surgery
KA Jacob, DE Leaf, JM Dieleman… - Journal of the …, 2015 - journals.lww.com
Administration of prophylactic glucocorticoids has been suggested as a strategy to reduce
postoperative AKI and other adverse events after cardiac surgery requiring cardiopulmonary
bypass. In this post hoc analysis of a large placebo-controlled randomized trial of
dexamethasone in 4465 adult patients undergoing cardiac surgery, we examined severe
AKI, defined as use of RRT, as a primary outcome. Secondary outcomes were doubling of
serum creatinine level or AKI-RRT, as well as AKI-RRT or in-hospital mortality (RRT/death) …
postoperative AKI and other adverse events after cardiac surgery requiring cardiopulmonary
bypass. In this post hoc analysis of a large placebo-controlled randomized trial of
dexamethasone in 4465 adult patients undergoing cardiac surgery, we examined severe
AKI, defined as use of RRT, as a primary outcome. Secondary outcomes were doubling of
serum creatinine level or AKI-RRT, as well as AKI-RRT or in-hospital mortality (RRT/death) …