Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast

F Balkwill, D Watling… - International journal of …, 1978 - Wiley Online Library
F Balkwill, D Watling, J Taylor‐Papadimitriou
International journal of cancer, 1978Wiley Online Library
Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial
cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon
concentration of 103 international units (IU) per ml, the inhibitory effects on monolayer
growth were completely reversible but the growth potential of cells at lower density in colony‐
forming cultures was not completely recovered. Studies on the cell cycle distribution of
interferon‐treated cells demonstrated that the growth‐inhibitory effect was not due to an …
Abstract
Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 103 international units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth potential of cells at lower density in colony‐forming cultures was not completely recovered. Studies on the cell cycle distribution of interferon‐treated cells demonstrated that the growth‐inhibitory effect was not due to an effect on one specific phase of the cell cycle, but to a lengthening of all phases.
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