[HTML][HTML] Ets-dependent regulation of target gene expression during megakaryopoiesis
P Jackers, G Szalai, O Moussa, DK Watson - Journal of Biological …, 2004 - ASBMB
Megakaryopoiesis is the process by which hematopoietic stem cells in the bone marrow
differentiate into mature megakaryocytes. The expression of megakaryocytic genes during
megakaryopoiesis is controlled by specific transcription factors. Fli-1 and GATA-1
transcription factors are required for development of megakaryocytes and promoter analysis
has defined in vitro functional binding sites for these factors in several megakaryocytic
genes, including GPIIb, GPIX, and C-MPL. Herein, we utilize chromatin immunoprecipitation …
differentiate into mature megakaryocytes. The expression of megakaryocytic genes during
megakaryopoiesis is controlled by specific transcription factors. Fli-1 and GATA-1
transcription factors are required for development of megakaryocytes and promoter analysis
has defined in vitro functional binding sites for these factors in several megakaryocytic
genes, including GPIIb, GPIX, and C-MPL. Herein, we utilize chromatin immunoprecipitation …