HIV-associated nephropathy: pathogenesis
RK Medapalli, JC He, PE Klotman - Current opinion in nephrology …, 2011 - journals.lww.com
RK Medapalli, JC He, PE Klotman
Current opinion in nephrology and hypertension, 2011•journals.lww.comHIVAN results from direct infection by HIV-1 and expression of viral genes, especially Nef
and Vpr, in renal epithelial cells in a genetically susceptible host. The infected renal
epithelium acts as a separate viral compartment from the blood and facilitates evolution of
strains distant from blood. Dysregulation of several host cellular pathways, including those
involved in cell cycle and apoptosis, ultimately results in the unique histopathological
syndrome of HIVAN.
and Vpr, in renal epithelial cells in a genetically susceptible host. The infected renal
epithelium acts as a separate viral compartment from the blood and facilitates evolution of
strains distant from blood. Dysregulation of several host cellular pathways, including those
involved in cell cycle and apoptosis, ultimately results in the unique histopathological
syndrome of HIVAN.
Summary
HIVAN results from direct infection by HIV-1 and expression of viral genes, especially Nef and Vpr, in renal epithelial cells in a genetically susceptible host. The infected renal epithelium acts as a separate viral compartment from the blood and facilitates evolution of strains distant from blood. Dysregulation of several host cellular pathways, including those involved in cell cycle and apoptosis, ultimately results in the unique histopathological syndrome of HIVAN.
Lippincott Williams & Wilkins