Relationship between CD107a expression and cytotoxic activity
E Aktas, UC Kucuksezer, S Bilgic, G Erten, G Deniz - Cellular immunology, 2009 - Elsevier
NK cells play important roles in innate immunity against tumors and infections of the host.
Studies show that CD107a (LAMP-1) may be a marker for degranulation of NK and activated
CD8+ T cells. In our study, the relationship between the expression of CD107a, cytokine
secretion and cytotoxic activity in CD56+ NK, CD8+ T cells and lymphocytes has been
determined after various stimuli. Effector cells from PBMCs of healthy subjects were isolated
and K562 cell line was used as target of cytotoxicity. IL-2 stimulation resulted in a significant …
Studies show that CD107a (LAMP-1) may be a marker for degranulation of NK and activated
CD8+ T cells. In our study, the relationship between the expression of CD107a, cytokine
secretion and cytotoxic activity in CD56+ NK, CD8+ T cells and lymphocytes has been
determined after various stimuli. Effector cells from PBMCs of healthy subjects were isolated
and K562 cell line was used as target of cytotoxicity. IL-2 stimulation resulted in a significant …
