[HTML][HTML] Natural killer T cells in cancer immunotherapy
S Nair, MV Dhodapkar - Frontiers in immunology, 2017 - frontiersin.org
S Nair, MV Dhodapkar
Frontiers in immunology, 2017•frontiersin.orgNatural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and
adaptive immune cells in the tumor microenvironment. This has impelled the development of
NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief
overview of the stimulatory and regulatory functions of NKT cells in tumor immunity as well
as highlight preclinical and clinical studies based on NKT cells. Finally, we discuss future …
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and
adaptive immune cells in the tumor microenvironment. This has impelled the development of
NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief
overview of the stimulatory and regulatory functions of NKT cells in tumor immunity as well
as highlight preclinical and clinical studies based on NKT cells. Finally, we discuss future …
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. This has impelled the development of NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief overview of the stimulatory and regulatory functions of NKT cells in tumor immunity as well as highlight preclinical and clinical studies based on NKT cells. Finally, we discuss future perspectives to better harness the potential of NKT cells for cancer therapy.
Frontiers