The mechanism of loss of CR1 during maturation of erythrocytes is different between factor I deficient patients and healthy donors
S Miot, J Marfurt, E Lach-Trifilieff… - Blood Cells, Molecules …, 2002 - Elsevier
During the in vivo maturation of erythrocytes, the number of CR1 per cell decreases by
approximately two-thirds in 30 days. The CR1 loss is enhanced in several diseases such as
SLE, AIDS, and particularly in factor I deficiency. Microvesicles enriched in CR1 and DAF
are released from erythrocytes matured in vitro, leading to the same loss of both molecules.
When comparing reticulocytes and erythrocytes, CR1 and DAF were lost similarly in 15
normal individuals, suggesting that vesiculation may be at the origin of CR1 loss in vivo …
approximately two-thirds in 30 days. The CR1 loss is enhanced in several diseases such as
SLE, AIDS, and particularly in factor I deficiency. Microvesicles enriched in CR1 and DAF
are released from erythrocytes matured in vitro, leading to the same loss of both molecules.
When comparing reticulocytes and erythrocytes, CR1 and DAF were lost similarly in 15
normal individuals, suggesting that vesiculation may be at the origin of CR1 loss in vivo …