[HTML][HTML] Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE)
JL Larabee, SM Shakir, S Barua, JD Ballard - Journal of Biological …, 2013 - ASBMB
In cells of the innate immune system, pathological increases in intracellular cAMP attenuate
immune responses and contribute to infections by bacteria such as Bacillus anthracis. In this
work, cAMP from B. anthracis edema toxin (ET) is found to activate the Notch signaling
pathway in both mouse macrophages and human monocytes. ET as well as a cell-
permeable activator of PKA induce Notch target genes (HES1, HEY1, IL2RA, and IL7R) and
are able to significantly enhance the induction of these Notch target genes by a Toll-like …
immune responses and contribute to infections by bacteria such as Bacillus anthracis. In this
work, cAMP from B. anthracis edema toxin (ET) is found to activate the Notch signaling
pathway in both mouse macrophages and human monocytes. ET as well as a cell-
permeable activator of PKA induce Notch target genes (HES1, HEY1, IL2RA, and IL7R) and
are able to significantly enhance the induction of these Notch target genes by a Toll-like …