Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease

M Thomsen, TS Ingebrigtsen, JL Marott, M Dahl… - Jama, 2013 - jamanetwork.com
Importance Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease
(COPD) have profound and long-lasting adverse effects on patients. Objective To test the
hypothesis that elevated levels of inflammatory biomarkers in individuals with stable COPD
are associated with an increased risk of having exacerbations. Design, Setting, and
Participants Prospective cohort study examining 61 650 participants with spirometry
measurements from the Copenhagen City Heart Study (2001-2003) and the Copenhagen …