[HTML][HTML] Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients
A Kök, L Hocqueloux, H Hocini, M Carrière, L Lefrou… - Mucosal …, 2015 - Elsevier
Massive loss of lamina propria CD4+ T cells, changes in the lymphatic architecture, and
altered intestinal epithelial barrier leading to microbial translocation are the common
features of HIV-1 infection and are not fully restored under combined antiretroviral therapy
(cART). To better understand determinants of gut mucosal restoration, we have performed
phenotypic and gene expression analyses of the gut from HIV-infected patients, naive or
treated with cART initiated either at the early phase of the primary infection or later during …
altered intestinal epithelial barrier leading to microbial translocation are the common
features of HIV-1 infection and are not fully restored under combined antiretroviral therapy
(cART). To better understand determinants of gut mucosal restoration, we have performed
phenotypic and gene expression analyses of the gut from HIV-infected patients, naive or
treated with cART initiated either at the early phase of the primary infection or later during …