Cardiac ryanodine receptor (Ryr2)-mediated calcium signals specifically promote glucose oxidation via pyruvate dehydrogenase
Cardiac ryanodine receptor (Ryr2) Ca 2+ release channels and cellular metabolism are both
disrupted in heart disease. Recently, we demonstrated that total loss of Ryr2 leads to
cardiomyocyte contractile dysfunction, arrhythmia, and reduced heart rate. Acute total Ryr2
ablation also impaired metabolism, but it was not clear whether this was a cause or
consequence of heart failure. Previous in vitro studies revealed that Ca 2+ flux into the
mitochondria helps pace oxidative metabolism, but there is limited in vivo evidence …
disrupted in heart disease. Recently, we demonstrated that total loss of Ryr2 leads to
cardiomyocyte contractile dysfunction, arrhythmia, and reduced heart rate. Acute total Ryr2
ablation also impaired metabolism, but it was not clear whether this was a cause or
consequence of heart failure. Previous in vitro studies revealed that Ca 2+ flux into the
mitochondria helps pace oxidative metabolism, but there is limited in vivo evidence …
