Diverse Nrf2 activators coordinated to cobalt carbonyls induce heme oxygenase-1 and release carbon monoxide in vitro and in vivo
A Nikam, A Ollivier, M Rivard, JL Wilson… - Journal of medicinal …, 2016 - ACS Publications
A Nikam, A Ollivier, M Rivard, JL Wilson, K Mebarki, T Martens, JL Dubois-Randé…
Journal of medicinal chemistry, 2016•ACS PublicationsThe Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection against oxidative
stress and cellular damage. We synthesized a series of cobalt-based hybrid molecules
(HYCOs) that combine an Nrf2 inducer with a releaser of carbon monoxide (CO), an anti-
inflammatory product of HO-1. Two HYCOs markedly increased Nrf2/HO-1 expression,
liberated CO and exerted anti-inflammatory activity in vitro. HYCOs also up-regulated tissue
HO-1 and delivered CO in blood after administration in vivo, supporting their potential use …
stress and cellular damage. We synthesized a series of cobalt-based hybrid molecules
(HYCOs) that combine an Nrf2 inducer with a releaser of carbon monoxide (CO), an anti-
inflammatory product of HO-1. Two HYCOs markedly increased Nrf2/HO-1 expression,
liberated CO and exerted anti-inflammatory activity in vitro. HYCOs also up-regulated tissue
HO-1 and delivered CO in blood after administration in vivo, supporting their potential use …
The Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection against oxidative stress and cellular damage. We synthesized a series of cobalt-based hybrid molecules (HYCOs) that combine an Nrf2 inducer with a releaser of carbon monoxide (CO), an anti-inflammatory product of HO-1. Two HYCOs markedly increased Nrf2/HO-1 expression, liberated CO and exerted anti-inflammatory activity in vitro. HYCOs also up-regulated tissue HO-1 and delivered CO in blood after administration in vivo, supporting their potential use against inflammatory conditions.
ACS Publications