The recruitment of peripheral monocytes to the sub-endothelial space, their development
into macrophages and subsequent proliferation are critical events during atherosclerosis.
Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid
lineage, but a role for them in atherogenesis has yet to be described. We have identified
functional EGF receptors (EGFR, ErbB1/HER-1) on peripheral blood monocytes and
monocyte-derived macrophages. Uniquely, these receptors were found to mediate both …