Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin
M Jaguin, N Houlbert, O Fardel, V Lecureur - Cellular immunology, 2013 - Elsevier
Monocytes/macrophages (MΦ), considered as plastic cells, can differentiate into either a pro-
inflammatory (M1) subtype, also known as a classically activated subtype, or an anti-
inflammatory alternatively activated subtype (M2) according to their microenvironment.
Phenotypic markers of mouse polarized MΦ have been extensively studied, whereas their
human counterparts remain less characterized. The main goal of this study was therefore to
carefully characterize phenotypic and genomic markers of primary human MΦ generated …
inflammatory (M1) subtype, also known as a classically activated subtype, or an anti-
inflammatory alternatively activated subtype (M2) according to their microenvironment.
Phenotypic markers of mouse polarized MΦ have been extensively studied, whereas their
human counterparts remain less characterized. The main goal of this study was therefore to
carefully characterize phenotypic and genomic markers of primary human MΦ generated …