Bone and the innate immune system

JF Charles, MC Nakamura - Current osteoporosis reports, 2014 - Springer
JF Charles, MC Nakamura
Current osteoporosis reports, 2014Springer
The immune system and bone are intimately linked with significant physical and functionally
related interactions. The innate immune system functions as an immediate response system
to initiate protections against local challenges such as pathogens and cellular damage.
Bone is a very specific microenvironment, in which infectious attack is less common but
repair and regeneration are ongoing and important functions. Thus, in the bone the primary
goal of innate immune and bone interactions is to maintain tissue integrity. Innate immune …
Abstract
The immune system and bone are intimately linked with significant physical and functionally related interactions. The innate immune system functions as an immediate response system to initiate protections against local challenges such as pathogens and cellular damage. Bone is a very specific microenvironment, in which infectious attack is less common but repair and regeneration are ongoing and important functions. Thus, in the bone the primary goal of innate immune and bone interactions is to maintain tissue integrity. Innate immune signals are critical for removal of damaged and apoptotic cells and to stimulate normal tissue repair and regeneration. In this review we focus on the innate immune mechanisms that function to regulate bone homeostasis.
Springer