Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice
E Ip, GC Farrell, G Robertson, P Hall, R Kirsch… - Hepatology, 2003 - Elsevier
We have proposed that steatohepatitis results from reactive oxygen species (ROS) acting on
accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a
(Cyp4a) and Cyp2e1 are potential hepatic sources of ROS. We tested the hypothesis that
increasing Cyp4a through activation of peroxisome proliferator-activated receptor α (PPARα)
should aggravate steatohepatitis produced by feeding a methionine and choline deficient
(MCD) diet. Conversely, we assessed dietary steatohepatitis in PPARα−/− mice that cannot …
accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a
(Cyp4a) and Cyp2e1 are potential hepatic sources of ROS. We tested the hypothesis that
increasing Cyp4a through activation of peroxisome proliferator-activated receptor α (PPARα)
should aggravate steatohepatitis produced by feeding a methionine and choline deficient
(MCD) diet. Conversely, we assessed dietary steatohepatitis in PPARα−/− mice that cannot …