Apolipoprotein AV; a potent triglyceride reducer
SK Nilsson, J Heeren, G Olivecrona, M Merkel - Atherosclerosis, 2011 - Elsevier
Since its discovery, apolipoprotein AV has been considered to be a potent factor affecting
plasma triglycerides (TG) in humans and mice. Several single nucleotide polymorphisms in
the APOA5 gene are associated with increased TG levels in humans, and some nonsense
mutations affecting protein structure predispose for familial hypertriglyceridemia and late
onset chylomicronemia. It is not clear, how apoA-V decreases plasma TG. There are three
major hypotheses: apolipoprotein AV could work through (1) an intracellular mechanism …
plasma triglycerides (TG) in humans and mice. Several single nucleotide polymorphisms in
the APOA5 gene are associated with increased TG levels in humans, and some nonsense
mutations affecting protein structure predispose for familial hypertriglyceridemia and late
onset chylomicronemia. It is not clear, how apoA-V decreases plasma TG. There are three
major hypotheses: apolipoprotein AV could work through (1) an intracellular mechanism …