cfDNA as a prognostic marker of response to taxane based chemotherapy in patients with prostate cancer
A Kienel, D Porres, A Heidenreich, D Pfister - The Journal of urology, 2015 - Elsevier
Purpose Chemotherapy is an integral part of the treatment of castration resistant prostate
cancer. With the introduction of new drugs the need to identify nonresponders is increasing.
To our knowledge there are no prognostic parameters to date for use upon the initiation of
any treatment. Materials and Methods cfDNA was isolated from a serum specimen before
chemotherapy. Its value was correlated to recurrence-free and overall survival using Kaplan-
Meier curves. Univariate and multivariate Cox regression analysis was performed to identify …
cancer. With the introduction of new drugs the need to identify nonresponders is increasing.
To our knowledge there are no prognostic parameters to date for use upon the initiation of
any treatment. Materials and Methods cfDNA was isolated from a serum specimen before
chemotherapy. Its value was correlated to recurrence-free and overall survival using Kaplan-
Meier curves. Univariate and multivariate Cox regression analysis was performed to identify …
