[HTML][HTML] Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry
GC Sparagna, CA Johnson, SA McCune… - Journal of lipid …, 2005 - ASBMB
Electrospray ionization mass spectrometry has previously been used to probe qualitative
changes in the phospholipid cardiolipin (CL), but it has rarely been used in a quantitative
manner. We assessed changes in the amount of individual molecular species of cardiac CL
present in a model of congestive heart failure using 1, 1′, 2, 2′-tetramyristoyl cardiolipin
as an internal standard. There was a linear relationship between the ratio of the negative
molecular ion ([MH]−) current from four different CL reference standards and the [MH]− from …
changes in the phospholipid cardiolipin (CL), but it has rarely been used in a quantitative
manner. We assessed changes in the amount of individual molecular species of cardiac CL
present in a model of congestive heart failure using 1, 1′, 2, 2′-tetramyristoyl cardiolipin
as an internal standard. There was a linear relationship between the ratio of the negative
molecular ion ([MH]−) current from four different CL reference standards and the [MH]− from …