[HTML][HTML] Role of taurine in the central nervous system

JY Wu, H Prentice - Journal of biomedical science, 2010 - Springer
JY Wu, H Prentice
Journal of biomedical science, 2010Springer
Taurine demonstrates multiple cellular functions including a central role as a
neurotransmitter, as a trophic factor in CNS development, in maintaining the structural
integrity of the membrane, in regulating calcium transport and homeostasis, as an osmolyte,
as a neuromodulator and as a neuroprotectant. The neurotransmitter properties of taurine
are illustrated by its ability to elicit neuronal hyperpolarization, the presence of specific
taurine synthesizing enzyme and receptors in the CNS and the presence of a taurine …
Abstract
Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating calcium transport and homeostasis, as an osmolyte, as a neuromodulator and as a neuroprotectant. The neurotransmitter properties of taurine are illustrated by its ability to elicit neuronal hyperpolarization, the presence of specific taurine synthesizing enzyme and receptors in the CNS and the presence of a taurine transporter system. Taurine exerts its neuroprotective functions against the glutamate induced excitotoxicity by reducing the glutamate-induced increase of intracellular calcium level, by shifting the ratio of Bcl-2 and Bad ratio in favor of cell survival and by reducing the ER stress. The presence of metabotropic taurine receptors which are negatively coupled to phospholipase C (PLC) signaling pathway through inhibitory G proteins is proposed, and the evidence supporting this notion is also presented.
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