Interaction of Cdk5 and cAMP/PKA signaling in the mediation of neuropsychiatric and neurodegenerative diseases
Y Hu, S Pan, HT Zhang - Phosphodiesterases: CNS Functions and …, 2017 - Springer
Y Hu, S Pan, HT Zhang
Phosphodiesterases: CNS Functions and Diseases, 2017•SpringerBoth cyclin-dependent kinase 5 (Cdk5) and cyclic AMP (cAMP)/protein kinase A (PKA)
regulate fundamental central nervous system (CNS) functions including neuronal survival,
neurite and axonal outgrowth, neuron development and cognition. Cdk5, a serine/threonine
kinase, is activated by p35 or p39 and phosphorylates multiple signaling components of
various pathways, including cAMP/PKA signaling. Here, we review the recent literature on
the interaction between Cdk5 and cAMP/PKA signaling and their role in the mediation of …
regulate fundamental central nervous system (CNS) functions including neuronal survival,
neurite and axonal outgrowth, neuron development and cognition. Cdk5, a serine/threonine
kinase, is activated by p35 or p39 and phosphorylates multiple signaling components of
various pathways, including cAMP/PKA signaling. Here, we review the recent literature on
the interaction between Cdk5 and cAMP/PKA signaling and their role in the mediation of …
Abstract
Both cyclin-dependent kinase 5 (Cdk5) and cyclic AMP (cAMP)/protein kinase A (PKA) regulate fundamental central nervous system (CNS) functions including neuronal survival, neurite and axonal outgrowth, neuron development and cognition. Cdk5, a serine/threonine kinase, is activated by p35 or p39 and phosphorylates multiple signaling components of various pathways, including cAMP/PKA signaling. Here, we review the recent literature on the interaction between Cdk5 and cAMP/PKA signaling and their role in the mediation of CNS functions and neuropsychiatric and neurodegenerative diseases.
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