RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
CF Bennett, EE Swayze - Annual review of pharmacology and …, 2010 - annualreviews.org
Dramatic advances in understanding of the roles RNA plays in normal health and disease
have greatly expanded over the past 10 years and have made it clear that scientists are only
beginning to comprehend the biology of RNAs. It is likely that RNA will become an
increasingly important target for therapeutic intervention; therefore, it is important to develop
strategies for therapeutically modulating RNA function. Antisense oligonucleotides are
perhaps the most direct therapeutic strategy to approach RNA. Antisense oligonucleotides …
have greatly expanded over the past 10 years and have made it clear that scientists are only
beginning to comprehend the biology of RNAs. It is likely that RNA will become an
increasingly important target for therapeutic intervention; therefore, it is important to develop
strategies for therapeutically modulating RNA function. Antisense oligonucleotides are
perhaps the most direct therapeutic strategy to approach RNA. Antisense oligonucleotides …
