[HTML][HTML] Cellular protection mechanisms against extracellular heme: heme-hemopexin, but not free heme, activates the N-terminal c-Jun kinase

JD Eskew, RM Vanacore, LM Sung, PJ Morales… - Journal of Biological …, 1999 - ASBMB
Hemopexin protects cells lacking hemopexin receptors by tightly binding heme abrogating
its deleterious effects and preventing nonspecific heme uptake, whereas cells with
hemopexin receptors undergo a series of cellular events upon encountering heme-
hemopexin. The biochemical responses to heme-hemopexin depend on its extracellular
concentration and range from stimulation of cell growth at low levels to cell survival at
otherwise toxic levels of heme. High (2–10 μm) but not low (0.01–1 μm) concentrations of …