[HTML][HTML] Severity of elastase-induced emphysema is decreased in tumor necrosis factor-α and interleukin-1β receptor-deficient mice
EC Lucey, J Keane, PP Kuang, GL Snider… - Laboratory …, 2002 - Elsevier
A single intratracheal dose of porcine pancreatic elastase, which is cleared from the lung by
24 hours, was administered to wild-type, IL-1β type 1 receptor-deficient, double TNF-α (type
1 and type 2) receptor-deficient, and combined TNF-α (type 1 receptor) plus IL-1β receptor-
deficient mice. The mean linear intercept (Lm) of saline-treated mice was 32 (3) μm [mean
(SE)]. For wild-type elastase-treated mice, Lm was 81 (6) μm at 21 days versus 52 (5) μm at
5 days after treatment, indicating that alveolar wall remodeling occurs long after the elastase …
24 hours, was administered to wild-type, IL-1β type 1 receptor-deficient, double TNF-α (type
1 and type 2) receptor-deficient, and combined TNF-α (type 1 receptor) plus IL-1β receptor-
deficient mice. The mean linear intercept (Lm) of saline-treated mice was 32 (3) μm [mean
(SE)]. For wild-type elastase-treated mice, Lm was 81 (6) μm at 21 days versus 52 (5) μm at
5 days after treatment, indicating that alveolar wall remodeling occurs long after the elastase …