Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol

P Ayala, J Montenegro, R Vivar, A Letelier… - … and molecular pathology, 2012 - Elsevier
Increasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various
diseases. In the human heart, ischemia/reperfusion has been correlated to ER stress, and
several markers of the unfolded protein response (UPR) participate during cardiac
remodeling and fibrosis. Here, we used isoproterenol (ISO) injection as a model for in vivo
cardiac fibrosis. ISO induced significant cardiomyocyte loss and collagen deposition in the
damaged areas of the endocardium. These responses were accompanied by an increase in …