Chlorine (Cl 2) gas exposure and toxicity remains a concern in military and industrial
sectors. While post-Cl 2 exposure damage to the lungs and other tissues has been
documented and major underlying mechanisms elucidated, no targeted therapeutics that
are effective when administered post-exposure, and which are amenable to mass-casualty
scenarios have been developed. Our recent studies show nitrite administered by
intramuscular (IM) injection post-Cl 2 exposure is effective in preventing acute lung injury …