Exposure to chlorine (Cl 2) gas can occur during accidents and intentional release
scenarios. However, biomarkers that specifically indicate Cl 2 exposure and Cl 2-derived
products that mediate postexposure toxicity remain unclear. We hypothesized that
chlorinated lipids (Cl-lipids) formed by direct reactions between Cl 2 gas and plasmalogens
serve as both biomarkers and mediators of post-Cl 2 gas exposure toxicities. The 2-
chloropalmitaldehyde (2-Cl-Pald), 2-chlorostearaldehyde (2-Cl-Sald), and their oxidized …