The binding of hemoglobin to haptoglobin and its relation to subunit dissociation of hemoglobin
RL Nagel, QH Gibson - Journal of Biological Chemistry, 1971 - ASBMB
The binding of liganded hemoglobin to haptoglobin, a plasma α 2-glycoprotein, is an
irreversible and stoichiometric reaction that occurs physiologically at the micromolar
concentration level. The study of the reaction between deoxyhemoglobin which does not
bind haptoglobin and a haptoglobin solution saturated with carbon monoxide indicates that
hemoglobin tetramer is incapable of binding haptoglobin and its dissociation to dimers is a
prerequisite for the reaction. The reaction between haptoglobin and the liganded dimers …
irreversible and stoichiometric reaction that occurs physiologically at the micromolar
concentration level. The study of the reaction between deoxyhemoglobin which does not
bind haptoglobin and a haptoglobin solution saturated with carbon monoxide indicates that
hemoglobin tetramer is incapable of binding haptoglobin and its dissociation to dimers is a
prerequisite for the reaction. The reaction between haptoglobin and the liganded dimers …