Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite–induced allergic asthma model

J Chesné, F Braza, G Chadeuf, G Mahay… - Journal of Allergy and …, 2015 - jacionline.org
LETTERS TO THE EDITOR 1643 chloride (KCl) ex vivo. The amplitude of contractile
responses to KCl and MCh in bronchi from Der f–treated mice was increased compared with
that of responses in bronchi from control mice and was not further enhanced by IL-17A (Fig
2, D). In contrast, IL-17A significantly enhanced both MCh-and KCl-induced contractions in
bronchi from control mice, reaching an amplitude similar to that of contractile responses in
bronchi from Der f–treated mice (Fig 2, D). Interestingly, this direct role of IL-17 in smooth …