[HTML][HTML] The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane …
W Zhang, Y Huang, SJ Gunst - Journal of Biological Chemistry, 2012 - ASBMB
The activation of the small GTPase RhoA is necessary for ACh-induced actin polymerization
and airway smooth muscle (ASM) contraction, but the mechanism by which it regulates
these events is unknown. Actin polymerization in ASM is catalyzed by the actin filament
nucleation activator, N-WASp and the polymerization catalyst, Arp2/3 complex. Activation of
the small GTPase cdc42, a specific N-WASp activator, is also required for actin
polymerization and tension generation. We assessed the mechanism by which RhoA …
and airway smooth muscle (ASM) contraction, but the mechanism by which it regulates
these events is unknown. Actin polymerization in ASM is catalyzed by the actin filament
nucleation activator, N-WASp and the polymerization catalyst, Arp2/3 complex. Activation of
the small GTPase cdc42, a specific N-WASp activator, is also required for actin
polymerization and tension generation. We assessed the mechanism by which RhoA …