The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome
A proportion of adenocarcinomas in prophylactic adnexectomies (bilateral salpingo-
oophorectomies [BSOs]) from women with BRCA mutations (BRCA positive) occur in the
fallopian tube. We analyzed a consecutive series of BSOs from BRCA-positive women
following an index case of fimbrial serous carcinoma. To determine if the fimbria is a
preferred site of origin, we followed a protocol for S ectioning and E xtensively E xamining
the FIM bria (SEE-FIM). Immunostaining for p53 and Ki-67 was also performed. Thirteen …
oophorectomies [BSOs]) from women with BRCA mutations (BRCA positive) occur in the
fallopian tube. We analyzed a consecutive series of BSOs from BRCA-positive women
following an index case of fimbrial serous carcinoma. To determine if the fimbria is a
preferred site of origin, we followed a protocol for S ectioning and E xtensively E xamining
the FIM bria (SEE-FIM). Immunostaining for p53 and Ki-67 was also performed. Thirteen …