[HTML][HTML] The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205
Epithelial-mesenchymal transition (EMT) is a physiological process that plays important
roles in tumor metastasis," stemness," and drug resistance. EMT is typically characterized by
the loss of the epithelial marker E-cadherin and increased expression of EMT-associated
transcriptional repressors, including ZEB1 and ZEB2. The miR-200 family and miR-205
prevent EMT through suppression of ZEB1/2. p53 has been implicated in the regulation of
miR-200c, but the mechanisms controlling miR-205 expression remain elusive. Here we …
roles in tumor metastasis," stemness," and drug resistance. EMT is typically characterized by
the loss of the epithelial marker E-cadherin and increased expression of EMT-associated
transcriptional repressors, including ZEB1 and ZEB2. The miR-200 family and miR-205
prevent EMT through suppression of ZEB1/2. p53 has been implicated in the regulation of
miR-200c, but the mechanisms controlling miR-205 expression remain elusive. Here we …