The diagnostic and biological implications of laminin expression in serous tubal intraepithelial carcinoma

E Kuhn, RJ Kurman, RA Soslow, G Han… - The American journal …, 2012 - journals.lww.com
There is compelling evidence to suggest that serous tubal intraepithelial carcinoma (STIC) is
the likely primary site for the development of many pelvic high-grade serous carcinomas
(HGSCs). Identifying molecules that are upregulated in STIC is important not only to provide
biomarkers to assist in the diagnosis of STIC but also to elucidate our understanding of the
pathogenesis of HGSC. In this study, we performed RNA sequencing to compare
transcriptomes between HGSC and normal fallopian tube epithelium (FTE), and we …