Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer

CP Crum, R Drapkin, D Kindelberger… - Clinical medicine & …, 2007 - Marshfield Clinic
Ovarian epithelial cancer is diagnosed in approximately 25,000 women yearly in the United
States, accounting for approximately 12,500 deaths. Of these tumors, serous cancer is the
most lethal, due to its capacity to spread beyond the reproductive tract and involve the
peritoneal surfaces or distant organs. Conventional classification systems designate tumor
origins principally on the location of the largest tumor. However, despite the fact that the
largest tumors typically involve the ovaries, demonstrations of a precise starting point for …