Serous carcinogenesis in the fallopian tube: a descriptive classification
E Jarboe, A Folkins, MR Nucci… - International Journal …, 2008 - journals.lww.com
The fimbria is the most common site of early serous cancer (tubal intraepithelial carcinoma
or STIC) in women with BRCA mutations (BRCA+). A candidate serous cancer precursor-the
p53 signature-has been found in nonneoplastic secretory cells of the fimbria, suggesting
serous carcinogenesis in the tube (SCAT). This study surveyed fallopian tubes from 3
populations to characterize the morphological and immunohistochemical correlates of
SCAT. The SCAT sequence was defined by strong nuclear p53 staining and DNA damage …
or STIC) in women with BRCA mutations (BRCA+). A candidate serous cancer precursor-the
p53 signature-has been found in nonneoplastic secretory cells of the fimbria, suggesting
serous carcinogenesis in the tube (SCAT). This study surveyed fallopian tubes from 3
populations to characterize the morphological and immunohistochemical correlates of
SCAT. The SCAT sequence was defined by strong nuclear p53 staining and DNA damage …