The distal fallopian tube: a new model for pelvic serous carcinogenesis

CP Crum, R Drapkin, A Miron, TA Ince… - Current Opinion in …, 2007 - journals.lww.com
CP Crum, R Drapkin, A Miron, TA Ince, M Muto, DW Kindelberger, Y Lee
Current Opinion in Obstetrics and Gynecology, 2007journals.lww.com
A fully characterized precursor lesion is a first and necessary step to pelvic serous cancer
prevention. The emerging data offer compelling evidence for a model of 'fimbrial-
ovarian'serous neoplasia, and call attention to the distal fallopian tube as an important
source for this disease, the study of which could clarify pathways to cancer in both organs
and generate novel strategies for cancer prevention.
Summary
A fully characterized precursor lesion is a first and necessary step to pelvic serous cancer prevention. The emerging data offer compelling evidence for a model of ‘fimbrial-ovarian’serous neoplasia, and call attention to the distal fallopian tube as an important source for this disease, the study of which could clarify pathways to cancer in both organs and generate novel strategies for cancer prevention.
Lippincott Williams & Wilkins