[HTML][HTML] Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions
Y Zhang, W Yan, X Chen - Journal of Biological Chemistry, 2011 - ASBMB
Mutant p53 is not only deficient in tumor suppression but also acquires additional activity,
called gain of function. Mutant p53 gain of function is recapitulated in knock-in mice that
carry one null allele and one mutant allele of the p53 gene. These knock-in mice develop
aggressive tumors compared with p53-null mice. Recently, we and others showed that tumor
cells carrying a mutant p53 are addicted to the mutant for cell survival and resistance to DNA
damage. To further define mutant p53 gain of function, we used the MCF-10A three …
called gain of function. Mutant p53 gain of function is recapitulated in knock-in mice that
carry one null allele and one mutant allele of the p53 gene. These knock-in mice develop
aggressive tumors compared with p53-null mice. Recently, we and others showed that tumor
cells carrying a mutant p53 are addicted to the mutant for cell survival and resistance to DNA
damage. To further define mutant p53 gain of function, we used the MCF-10A three …