Novel monoclonal antibodies against the proximal (carboxy-terminal) portions of MUC16

TD Rao, KJ Park, P Smith-Jones… - Applied …, 2010 - journals.lww.com
The CA125 antigen, recognized by the OC125 antibody, is a tissue-specific circulating
antigen expressed in ovarian cancer. The CA125 antigen is encoded by the MUC16 gene
cloned by Yin and Lloyd. The full-length gene describes a complex tethered mucin protein
present primarily in a variety of gynecologic tissues, especially neoplasms. OC125 and other
related antibodies react with glycosylation-dependent antigens present exclusively in the
cleaved portion of the molecule. These antibodies are not useful as screening tools, nor can …